Enzyme Inhibition
Enzyme inhibiton The enzymatic reaction may be altered by a moderator. In some cases, the enzyme action can be reduced or inhibited and in some other cases the action can be enhanced. If the effect is to reduce the rate, and this is called inhibition and enhanced it is called activation. Inhibitors are molecules, which inhibit or antagonize the actions of Enzymes, thereby inhibiting the enzyme catalyzed reaction. The reduced enzymatic rate due to change in pH, temperature etc is not considered as inhibition. Inhibition is broadly classified as two major types. Irreversible and reversible inhibition. Reversible Inhibition Here the enzyme action can be reversed even after the inhibition. Usually the compound or the inhibitor binds to the enzyme by weak interactions. No covalent bond occurs here. Reversible inhibitors are classified into competitive, noncompetitive and uncompetitive. Competitive inhibition Competitive inhibitors bind only to free enzyme molecules. Here the inhi